We developed a new method to detect recent recombinant sequences without the need for a reference panel, and demonstrate its application to malaria parasite var genes that are highly recombinogenic.
We characterized age-specific patterns of P. falciparum variant antigen gene diversity in residents of a highly endemic setting in Bongo, Ghana and used these data to simulate the development of variant-specific immunity over an individuals lifetime. This article has been accepted in International Journal for Parasitology.
We developed a luminex-based serological assay for measuring antibodies to a panel of SARS-CoV-2 and other respiratory virus antigens.
We show how parasite genetics can be harnessed to better understand the efficacy of malaria control interventions, particularly by identifying key factors leading to parasite resilience that may not be reflected in other commonly used evaluation metrics. This work was chosen by the Molecular Ecology editors to be featured on their blog.
We describe the genomic epidemiology of continued malaria disease transmission in Ecuador after and outbreak and explore whether clinical cases are imported or locally-acquired.
We described population structure at of the highly diverse genes encoding the immunodominant surface antigen of P. falciparum at the global scale. This work was chosen by the PLOS Genetics editors to be featured with an accompanying Perspectives piece.
We described the evolution of P. falciparum antimalarial drug resistance in Bongo, Ghana
We used temporal multilayer networks to analyze the genetic similarity of malaria parasites.
We developed models that encompass malaria epidemiology and evolution to examine immune selection signatures.
We explored the evolutionary and ecological dynamics of P. falciparum antigenic diversity.
We investigated the population genomics of var genes in cases of uncomplicated malaria in Uganda.
We examined the population genetics of the asymptomatic P. falciparum reservoir in Ghana.